Recognition of Multiple Methyl Groups on Aromatic Rings by a Polyaromatic Cavity

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• 作者：Dr. Masahiro Yamashina ; Sho Matsuno ; Dr. Yoshihisa Sei ; Prof. Dr. Munetaka Akita and Dr. Michito Yoshizawa
• 刊名：Chemistry - A European Journal
• 出版年：2016
• 出版时间：September 26, 2016
• 年：2016
• 卷：22
• 期：40
• 页码：14147-14150
• 全文大小：2597K
• ISSN：1521-3765

文摘

The methyl group is a small substituent, usually showing relatively weak or no interactions with other functional groups and metal ions. Herein, we present the recognition of the number of methyl groups on synthetic and natural aromatic compounds (i.e., benzene and xanthine derivatives, respectively) by the 1 nm-sized polyaromatic cavity of a coordination capsule in water. Detailed competitive encapsulation experiments as well as X-ray crystallographic analysis revealed that multiple guest–host CH₃–polyaromatic interactions in the confined nanospace are key driving forces for the high selectivity.