An Efficient Synthesis of Tetracyclic Pyrano[2,3-d]pyrimidines

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• 作者：Zhi-Lan Lin ; Jun-Min Zhang and Yuan Gao
• 刊名：Journal of Heterocyclic Chemistry
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：54
• 期：1
• 页码：596-602
• 全文大小：624K
• ISSN：1943-5193

文摘

A series of pyrano[2,3-d]pyrimidine derivatives have been synthesized by the reaction of 2-amino-3-cyano-4H-pyrans and acetic anhydride with acid catalyst . This method is very efficient because of short reaction times and easy work-up, and it provides an efficient and promising synthetic strategy for the construction of the tetracyclic pyrano[2,3-d]pyrimidine skeleton. The X-ray crystal structures of products are confirmed, and the possible mechanism is provided in this paper.