Cover Picture: Copper(II)/Silver(I)-Catalyzed Sequential Alkynylation and Annulation of Aliphatic Amides with Alkynyl Carboxylic Acids: Efficient Synthesis of Pyrrolidones (Adv. Synth. Catal. 5/2016)

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• 作者：Jitan Zhang ; Danyang Li ; Hui Chen ; Binjie Wang ; Zhanxiang Liu and Yuhong Zhang
• 关键词：alkynylation/annulations ; C&ndash ; H activation ; copper ; decarboxylation ; pyrrolidones
• 刊名：Advanced Synthesis & Catalysis
• 出版年：2016
• 出版时间：March 3, 2016
• 年：2016
• 卷：358
• 期：5
• 页码：674
• 全文大小：3820K
• ISSN：1615-4169

文摘

The cover picture, provided by Yuhong Zhang and co-workers, illustrates a highly efficient synthesis of pyrrolidones by the copper-catalyzed alkynylation/annulation of aliphatic amides with alkynyl carboxylic acids. A broad range of easily accessible alkynyl carboxylic acids was introduced at the β-methyl group of aliphatic amides with the assistance of an 8-aminoquinolyl auxiliary group via decarboxylation to achieve the subsequent cyclic CN bond formation within one hour. This catalytic tandem decarboxylative cyclization provides a new opportunity for the direct functionalization of sp³ CH bonds. Details can be found in the full paper on pages 792–807 (J. Zhang, D. Li, H. Chen, B. Wang, Z. Liu, Y. Zhang, Adv. Synth. Catal.­ 2016, 358, 792–807; DOI: 10.1002/adsc.201500727).