Elevation of Brain Magnesium Potentiates Neural Stem Cell Proliferation in the Hippocampus of Young and Aged Mice

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• 作者：Shanshan Jia ; Yunpeng Liu ; Yang Shi ; Yihe Ma ; Yixin Hu ; Meiyan Wang and Xue Li
• 刊名：Journal of Cellular Physiology
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：231
• 期：9
• 页码：1903-1912
• 全文大小：8060K
• ISSN：1097-4652

文摘

In the adult brain, neural stem cells (NSCs) can self-renew and generate all neural lineage types, and they persist in the sub-granular zone (SGZ) of the hippocampus and the sub-ventricular zone (SVZ) of the cortex. Here, we show that dietary-supplemented - magnesium-L-threonate (MgT), a novel magnesium compound designed to elevate brain magnesium regulates the NSC pool in the adult hippocampus. We found that administration of both short- and long-term regimens of MgT, increased the number of hippocampal NSCs. We demonstrated that in young mice, dietary supplementation with MgT significantly enhanced NSC proliferation in the SGZ. Importantly, in aged mice that underwent long-term (12-month) supplementation with MgT, MgT did not deplete the hippocampal NSC reservoir but rather curtailed the age-associated decline in NSC proliferation. We further established an association between extracellular magnesium concentrations and NSC self-renewal in vitro by demonstrating that elevated Mg²⁺ concentrations can maintain or increase the number of cultured hippocampal NSCs. Our study also suggests that key signaling pathways for cell growth and proliferation may be candidate targets for Mg²⁺'s effects on NSC self-renewal. J. Cell. Physiol. 231: 1903–1912, 2016.