A potential insect growth regulator for cockroach control: design, synthesis and bioactivity of N-terminal-modified allatostatin analogues

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• 作者：Xiaoqing Wu ; Meizi Wang ; Juan Huang ; Li Zhang ; Zhe Zhang ; Yun Ling ; Xinling Yang and Stephen S Tobe
• 刊名：Pest Management Science
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：73
• 期：3
• 页码：500-505
• 全文大小：734K
• ISSN：1526-4998

文摘

The FGLa-allatostatins (ASTs) are a family of neuropeptides that can inhibit juvenile hormone biosynthesis by the corpora allata (CA) in vitro, and therefore they are regarded as insect growth regulator (IGR) candidates for pest control. In our previous studies, an AST mimic, H17, was found to have a significant effect on JH biosynthesis by cockroach CA, both in vitro and in vivo. To discover new potential mimics and explore the substituent effect on the inhibition of JH biosynthesis, 30 analogues, modified with various substituents on the benzene ring at the N-terminus of lead compound H17, were designed and synthesised. Their bioactivity in inhibiting JH biosynthesis by the CA of Diploptera punctata and the potency of M9, M10 and M11 in activation of Dippu-AstR were evaluated.