ChemInform Abstract: Multicomponent Reaction of Pyridine, Acetoacetamide/Benzoylacetamides and Sulfuryl Chlorides: Regioselective Construction of 4-Olefinated Dihydropyridines.

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• 作者：Xuna Zhao ; Tong-Xin Liu ; Nana Ma ; Zhiguo Zhang and Guisheng Zhang
• 刊名：ChemInform
• 出版年：2016
• 出版时间：November, 2016
• 年：2016
• 卷：47
• 期：47
• 全文大小：34K
• ISSN：1522-2667

文摘

A one-pot, three-component coupling reaction of pyridine, β-keto amides, and sulfonyl chlorides yields 4-alkenyl-1,4-dihydropyridines under mild conditions via sequential activation of pyridine by the sulfonyl chloride and nucleophilic addition of in situ generated acylacetonitrile.