Pharmacokinetics cannot explain the increased effective dose requirement for morphine and midazolam in rats during their extended administration alone or in combination

详细信息    查看全文

• 作者：Stefan J. Schaller ; Saad M. Alam ; Jianren Mao ; Yanli Zhao ; Manfred Blobner ; David J. Greenblatt and J.A. Jeevendra Martyn
• 刊名：Journal of Pharmacy and Pharmacology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：69
• 期：1
• 页码：82-88
• 全文大小：298K
• ISSN：2042-7158

文摘

Chronic administration of morphine and midazolam, alone or in combination, can induce tolerance to their effects. Data showed that co-administration of morphine and midazolam increased effective dose requirement of morphine, exceeding that observed with morphine alone.