Back Cover: A Platinum(IV) Anticancer Prodrug Targeting Nucleotide Excision Repair To Overcome Cisplatin Resistance (Angew. Chem. Int. Ed. 50/2016)

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• 作者：Zhigang Wang ; Zoufeng Xu and Prof. Dr. Guangyu Zhu
• 刊名：Angewandte Chemie International Edition
• 出版年：2016
• 出版时间：December 12, 2016
• 年：2016
• 卷：55
• 期：50
• 页码：15690
• 全文大小：6068K
• ISSN：1521-3773

文摘

DNA damage repair plays key roles not only in maintaining genome integrity but also in reducing the antitumor efficacy of DNA-damaging antineoplastics. In their Communication on page 15564 ff., G. Zhu et al. describe a Pt^IV anticancer prodrug targeting nucleotide excision repair (NER) to overcome cisplatin resistance. This dual-action prodrug with both cisplatin and NER inhibitor moieties causes DNA damage and inhibits NER, which leads to significantly increased cytotoxicity in cisplatin-resistant human cancer cells.