In Silico Assessment of the Potential of Patatin as a Precursor of Bioactive Peptides

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• 作者：Yu Fu ; Wei Wu ; Minpeng Zhu and Zhigang Xiao
• 刊名：Journal of Food Biochemistry
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：40
• 期：3
• 页码：366-370
• 全文大小：79K
• ISSN：1745-4514

文摘

The aim of this study was to evaluate patatin, a major storage protein in potato tuber, as a precursor of bioactive peptides based on in silico approaches. In silico proteolysis of patatin using 16 proteases released numerous bioactive peptides exhibiting antioxidant, angiotensin-I converting enzyme (ACE) inhibitory, dipeptidyl peptidase (DPP)-IV inhibitory, glucose uptake, neuropeptide inhibitory and ion flow-regulating capacities. Chymotrypsin C released the most bioactive sequences from patatin compared with other proteases. In addition, the results of PeptideRanker demonstrated that a number of di- and tripeptides derived from patatin possessed great potential as bioactive peptides.