ChemInform Abstract: Rhodium-Catalyzed Tandem C—H Activation and Aza-Michael Addition of 2-Arylquinazolin-4-ones with Acrylates for the Synthesis of Pyrrolo[2,1-b]quinazolin-9(1H)-one Derivatives.
A tandem C—H activation/aza-Michael reaction of quinazolinones (I) with acrylic esters is achieved in the presence of a dual Rh/Ag-catalyst to provide pyrrolo[2.1-b]quinazolin-9(1H)-ones in good to excellent yields.