Photoredox Catalysis A visible light-mediated [3+3] annulation of tertiary amines with α-trifluoromethyl alkenes was developed. The reaction offers a direct route to fluorinated tetrahydropyridines and azabicyclo[3.
m.1] frameworks under very mild conditions. This protocol presents a rare example of dual sp<
sup>3
sup> C−H functionalization of tertiary amines with the formation of two different C−C bonds (one sp<
sup>3
sup>−sp<
sup>3
sup> bond, one sp<
sup>2
sup>−sp<
sup>3
sup> bond). Moreover, two consecutive C−F
substitutions in a trifluoromethyl group were achieved in one-pot using visible light photoredox catalysis, which enables an unprecedented ring construction. More information can be found in the Communication by L.
Zhou et al. on
page 2249 ff.