One-Pot Synthesis of 4-Heteroaryl-Substituted Pyrazoles: A Gold-Catalyzed Oxidation/1,2-Heteroaryl Migration Cascade Constitutes the Key Step
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- 作者：Xinbo Yao ; Tao Wang ; Xi Zhang ; Ping Wang ; Bing Zhang ; Junfa Wei and Zunting Zhang
- 关键词：1 ; 3-diketones ; gold carbenes ; gold catalysis ; heterocycles ; pyrazoles
- 刊名：Advanced Synthesis & Catalysis
- 出版年：2016
- 出版时间：April 28, 2016
- 年：2016
- 卷：358
- 期：9
- 页码：1534-1539
- 全文大小：1223K
- ISSN：1615-4169
文摘
An efficient gold-catalyzed oxidation/1,2- heteroaryl migration cascade leading to 2-heteroaryl-substituted 1,3-diketones and its further application in the one-pot synthesis of 4-heteroaryl-substituted pyrazoles and the preparation of 4-heteroaryl-substituted isoxazoles are reported. A wide variety of 4-heteroaryl-substituted pyrazoles were obtained, indicating the broad substrate scope and functional group tolerance of this method.