(−)-Epicatechin induces physiological cardiac growth by activation of the PI3K/Akt pathway in mice
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- 作者：Sergio De los Santos ; Viridiana Garcí ; a-Pé ; rez ; Sauri Herná ; ndez-Resé ; ndiz ; Carlos Palma-Flores ; Carlos J. Gonzá ; lez-Gutié ; rrez ; Cecilia Zazueta ; Patricia Canto and Ramó ; n M. Coral-Vá ; zquez
- 刊名：Molecular Nutrition & Food Research
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：61
- 期：2
- 全文大小：1465K
- ISSN：1613-4133
文摘
The flavanol (−)-epicatechin (Epi) has cardioprotective effects and improves physical capacity in normal mice. In addition, Epi increases nitric oxide (NO) production by activation of both PI3K/Akt or Cap>2+ p>/CaMI/CaMKII (where Akt is protein kinase B; PI3K is phosphoinositide 3-kinase; CaMI is calmodulin; CaMKII is Cap>2+ p>/calmodulin-dependent protein kinase II) signaling pathways, which have been associated with physiological and pathological cardiac hypertrophy, respectively. Notwithstanding all this information, few studies have been carried out that aimed to determine the potential beneficial effects that Epi may have in normal heart.