文摘
The synthesis of a metalled double-helix containing exclusively silver-mediated C*−C* base pairs is reported herein (C*=Np>1p>hexylcytosine). Remarkably, it is the first crystal structure containing infinite and consecutive C*-Agp>Ip>-C* base pairs that form a double helix. The Agp>Ip> ion occupies the center between two C* residues with N(3)−Ag bond lengths of 2.1 Å and short Agp>Ip>−Agp>Ip> distances (3.1 Å) suggesting an interesting argentophilic attraction as a stabilization source of the helical disposition. The solid-state structure is further stabilized by metal-mediated base-pairs, hydrogen bonding and π-stacking interactions. Moreover, the angle N(3)−Ag-N(3) is almost linear in the [Ag(Np>1p>hexylcytosine)2]p>+p> motif and the bases are not coplanar, thus generating a double-strand helical aggregate in the solid state. The noncovalent and argentophilic interactions have been rationalized based on DFT calculations.