Synthesis and Evaluation of Novel 5-cyclohexyl-2-(4″-substitutedphenyl)-3-(2″-substitutedphenyl)4m>Hm>-2,3,3a,5,6,6a-hexahydropyrrolo[3,4-m>dm>]isoxazole-4,6-dione Derivatives for Their m>In Vitrom> Antioxidant and Antibacterial Activities

详细信息    查看全文

• 作者：Manpreet Kaur ; Anjandeep Kaur ; Baldev Singh and Baljit Singh
• 刊名：Journal of Heterocyclic Chemistry
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：54
• 期：1
• 页码：80-88
• 全文大小：307K
• ISSN：1943-5193

文摘

m4">1,3-Dipolar cycloaddition reactions of mlns:w="http://www.wiley.com/namespaces/wiley" xmlns:cr="urn://wiley-online-library/content/render" xmlns:mml="http://www.w3.org/1998/Math/MathML" id="jhet2543-eo-0001">m3">m>Nm>-cyclohexyl maleimide () with azomethine m>Nm>-oxide () have afforded novel isoxazolidine () in excellent yield. Their structures have been characterized from their IR, ¹H-NMR, ¹³C-NMR, ¹H,¹H-COSY, MS(ESI), and elemental analysis techniques. m>In vitrom> m6">antibacterial activity of the synthesized compounds were investigated against a representative panel of pathogenic strains specifically two Gram-positive bacteria (m>Staphylococcus aureusm> and m>Streptococcus pyogenesm>) and two Gram-negative bacteria (m>Pseudomonas aeruginosam> and m>Escherichia colim>) using agar-well diffusion assay. Some of the compounds (, , , and ) exhibited promising antibacterial activities. All the synthesized compounds have also been screened for their antioxidant activities and were found to be significantly active.