Role of indoleamine 2,3-dioxygenase in an inflammatory model of murine gingiva
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- 作者：X. Qin ; J. Y. Liu ; T. Wang ; D. H. Pashley ; A. H. Al-Hashim ; R. Abdelsayed ; J. C Yu ; M.S. Mozaffari and B. Baban
- 刊名：Journal of Periodontal Research
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：52
- 期：1
- 页码：107-113
- 全文大小：810K
- ISSN：1600-0765
文摘
Indoleamine 2,3-dioxygenase (IDO) is one of the major pathways for metabolism of tryptophan in a variety of cells, including immune cells. Increasing evidence indicates that IDO is a critical player in establishing the balance between immunity and tolerance and ultimately in the maintenance of homeostasis. By inducing inflammation in gingival tissue, we tested the hypothesis that IDO is a pivotal player in regulating the immune and inflammatory responses of gingiva.