Synthesis of Cytotoxic Isodeoxypodophyllotoxin Analogs

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• 作者：Babak Heidary Alizadeh ; Saeed Emami ; Gholamreza Dehghan ; Alireza Foroumadi and Abbas Shafiee
• 刊名：Journal of Heterocyclic Chemistry
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：54
• 期：1
• 页码：539-545
• 全文大小：540K
• ISSN：1943-5193

文摘

A series of aryltetralin lignans jhet2618-eo-0007" rel="references:#jhet2618-eo-0007 #jhet2618-eo-0008 #jhet2618-eo-0009 #jhet2618-eo-0010 #jhet2618-eo-0011 #jhet2618-eo-0012 #jhet2618-eo-0013 #jhet2618-eo-0014 #jhet2618-eo-0015 #jhet2618-eo-0016 #jhet2618-eo-0017 #jhet2618-eo-0018"> were synthesized as cytotoxic isodeoxypodophyllotoxin analogs. The title compounds jhet2618-eo-0007" rel="references:#jhet2618-eo-0007 #jhet2618-eo-0008 #jhet2618-eo-0009 #jhet2618-eo-0010 #jhet2618-eo-0011 #jhet2618-eo-0012 #jhet2618-eo-0013 #jhet2618-eo-0014 #jhet2618-eo-0015 #jhet2618-eo-0016 #jhet2618-eo-0017 #jhet2618-eo-0018"> were synthesized from the reaction of (+)-(R)-4-[benzo(d)(1,3)dioxol-5-ylmethyl]-dihydrofuran-2-(3H)-one with different arylaldehydes to afford benzyl alcohol analogs and subsequent cyclization with trifluoroacetic acid in dichromethane. The preliminary screening of the compounds against viability of blood cancer human cell line K562 revealed that compounds jhet2618-eo-0010" rel="references:#jhet2618-eo-0010">, jhet2618-eo-0011" rel="references:#jhet2618-eo-0011">, and jhet2618-eo-0012" rel="references:#jhet2618-eo-0012"> had higher inhibitory activity at 10 µg/mL concentration compared with etoposide as reference drug.