Genetic polymorphisms in UDP-glucuronosyltransferase 1A6 and 1A7 and the risk for benign Warthin's tumors of the parotid gland
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- 作者：Martin Lacko ; Adri C. Voogd ; Rens C.E. van de Goor ; Hennie M.J. Roelofs ; Rene H.M. te Morsche ; Nicole D. Bouvy ; Wilbert H.M. Peters and Johannes J. Manni
- 关键词：Warthin's tumor ; genetic predisposition ; biotransformation enzyme ; parotid neoplasm ; UDP-glucuronosyltransferase
- 刊名：Head & Neck
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：38
- 期：S1
- 页码：E717-E723
- 全文大小：93K
- ISSN：1097-0347
文摘
Warthin's tumors of the parotid gland are associated with smoking, whereas pleomorphic adenomas are not. Genetic polymorphisms in biotransformation enzymes, involved in detoxification of toxins and carcinogens in cigarette smoke, might modify the corresponding enzyme activity and influence detoxifying capacity. We hypothesize that these genetic polymorphisms may influence the individual risk for Warthin's tumor, but not for pleomorphic adenomas.