Ebola Vaccination Using a DNA Vaccine Coated on PLGA-PLL/γPGA Nanoparticles Administered Using a Microneedle Patch

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• 作者：Hung-Wei Yang ; Ling Ye ; Xin Dong Guo ; Chinglai Yang ; Richard W. Compans and Mark R. Prausnitz
• 刊名：Advanced Healthcare Materials
• 出版年：2017
• 出版时间：January 11, 2017
• 年：2017
• 卷：6
• 期：1
• 全文大小：1085K
• ISSN：2192-2659

文摘

Ebola DNA vaccine is incorporated into PLGA-PLL/γPGA nanoparticles and administered to skin using a microneedle (MN) patch. The nanoparticle delivery system increases vaccine thermostability and immunogenicity compared to free vaccine. Vaccination by MN patch produces stronger immune responses than intramuscular administration.