Silencing of Prrx1b suppresses cellular proliferation, migration, invasion and epithelial-mesenchymal transition in triple-negative breast cancer
详细信息 查看全文
- 作者：Zhi-Dong Lv ; Zhao-Chuan Yang ; Xiang-Ping Liu ; Li-Ying Jin ; Qian Dong ; Hui-Li Qu ; Fu-Nian Li ; Bin Kong ; Jiao Sun ; Jiao-Jiao Zhao and Hai-Bo Wang
- 刊名：Journal of Cellular and Molecular Medicine
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：20
- 期：9
- 页码：1640-1650
- 全文大小：916K
- ISSN：1582-4934
文摘
Triple-negative breast cancer (TNBC) is a highly aggressive tumour subtype associated with poor prognosis. The mechanisms involved in TNBC progression remains largely unknown. To date, there are no effective therapeutic targets for this tumour subtype. Paired-related homeobox 1b (Prrx1b), one of major isoforms of Prrx1, has been identified as a new epithelial–mesenchymal transition (EMT) inducer. However, the function of Prrx1b in TNBC has not been elucidated. In this study, we found that Prrx1b was significantly up-regulated in TNBC and associated with tumour size and vascular invasion of breast cancer. Silencing of Prrx1b suppressed the proliferation, migration and invasion of basal-like cancer cells. Moreover, silencing of Prrx1b prevented Wnt/β-catenin signaling pathway and induced the mesenchymal-epithelial transition (MET). Taken together, our data indicated that Prrx1b may be an important regulator of EMT in TNBC cells and a new therapeutic target for interventions against TNBC invasion and metastasis.