Synthesis of Ferromagnetic Fe0.6Mn0.4O Nanoflowers as a New Class of Magnetic Theranostic Platform for In Vivo T1-T2 Dual-Mode Magnetic Resonance Imaging and Magnetic Hyperthermia Therapy

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• 作者：Xiao Li Liu ; Cheng Teng Ng ; Prashant Chandrasekharan ; Hai Tao Yang ; Ling Yun Zhao ; Erwin Peng ; Yun Bo Lv ; Wen Xiao ; Jie Fang ; Jia Bao Yi ; Huan Zhang ; Kai-Hsiang Chuang ; Boon Huat Bay ; Jun Ding and Hai Ming Fan
• 刊名：Advanced Healthcare Materials
• 出版年：2016
• 出版时间：August 24, 2016
• 年：2016
• 卷：5
• 期：16
• 页码：2092-2104
• 全文大小：3492K
• ISSN：2192-2659

文摘

Uniform wüstite Fe_0.6Mn_0.4O nanoflowers have been successfully developed as an innovative theranostic agent with T₁-T₂ dual-mode magnetic resonance imaging (MRI), for diagnostic applications and therapeutic interventions via magnetic hyperthermia. Unlike their antiferromagnetic bulk counterpart, the obtained Fe_0.6Mn_0.4O nanoflowers show unique room-temperature ferromagnetic behavior, probably due to the presence of an exchange coupling effect. Combined with the flower-like morphology, ferromagnetic Fe_0.6Mn_0.4O nanoflowers are demonstrated to possess dual-modal MRI sensitivity, with longitudinal relaxivity r₁ and transverse relaxivity r₂ as high as 4.9 and 61.2 mm⁻¹s⁻¹ [Fe]+[Mn], respectively. Further in vivo MRI carried out on the mouse orthotopic glioma model revealed gliomas are clearly delineated in both T₁- and T₂-weighted MR images, after administration of the Fe_0.6Mn_0.4O nanoflowers. In addition, the Fe_0.6Mn_0.4O nanoflowers also exhibit excellent magnetic induction heating effects. Both in vitro and in vivo magnetic hyperthermia experimentation has demonstrated that magnetic hyperthermia by using the innovative Fe_0.6Mn_0.4O nanoflowers can induce MCF-7 breast cancer cell apoptosis and a complete tumor regression without appreciable side effects. The results have demonstrated that the innovative Fe_0.6Mn_0.4O nanoflowers can be a new magnetic theranostic platform for in vivo T₁-T₂ dual-mode MRI and magnetic thermotherapy, thereby achieving a one-stop diagnosis cum effective therapeutic modality in cancer management.