Investigating tumor perfusion by hyperpolarized ¹³C MRI with comparison to conventional gadolinium contrast-enhanced MRI and pathology in orthotopic human GBM xenografts

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• 作者：Ilwoo Park ; Cornelius von Morze ; Janine M. Lupo ; Jan H. Ardenkjaer-Larsen ; Achuta Kadambi ; Daniel B. Vigneron and Sarah J. Nelson
• 刊名：Magnetic Resonance in Medicine
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：77
• 期：2
• 页码：841-847
• 全文大小：2969K
• ISSN：1522-2594

文摘

Dissolution dynamic nuclear polarization (DNP) enables the acquisition of ¹³C magnetic resonance data with a high sensitivity. Recently, metabolically inactive hyperpolarized ¹³C-labeled compounds have shown to be potentially useful for perfusion imaging. The purpose of this study was to validate hyperpolarized perfusion imaging methods by comparing with conventional gadolinium (Gd)-based perfusion MRI techniques and pathology.