Tumor Visualization: Branched Gold Nanoparticle Coating of Clostridium novyi-NT Spores for CT-Guided Intratumoral Injection (Small 5/2017)

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• 作者：Wooram Park ; Soojeong Cho ; Xiaoke Huang ; Andrew C. Larson and Dong-Hyun Kim
• 刊名：Small
• 出版年：2017
• 出版时间：February 3, 2017
• 年：2017
• 卷：13
• 期：5
• 全文大小：3247K
• ISSN：1613-6829

文摘

Anaerobic Clostridium novyi-NT (C. novyi-NT) has proved to be effective for treating tumors. X-ray computed tomography (CT) image guided delivery of this strain of bacteria to tumors has several great advantages over previous methods. In article number 1602722, A. C. Larson, D.-H. Kim, and co-workers developed an approach to coat the surface of C. novyi-NT spores with gold nanoparticles for CT-guided bacteriolytic therapy. Branched gold nanoparticles-coated spores are successfully injected into a tumor site under CT image guidance. A strong anti-tumor effect was observed in the in vivo tumor model.