TRPA1 receptor is upregulated in human oral lichen planus

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• 作者：J Kun ; A Perkecz ; L Knie ; G S&eacute ; tá ; ló ; Jr ; T Tornó ; czki ; E Pint&eacute ; r and Á ; Bá ; n
• 刊名：Oral Diseases
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：23
• 期：2
• 页码：189-198
• 全文大小：1279K
• ISSN：1601-0825

文摘

Oral lichen planus (OLP) is a chronic inflammatory disease of unknown etiology with antigen-specific and non-specific mechanisms. Transient receptor potential ankyrin 1 (TRPA1) is a non-selective cation channel activated by noxious stimuli such as oxidative stress products evoking pain and release of proinflammatory mediators from sensory nerve endings culminating in neurogenic inflammation. Extraneuronal TRPA1s, for example, on immune cells possess yet unknown functions.