AAZTA: An Ideal Chelating Agent for the Development of <sup>44sup>Sc PET Imaging Agents
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- 作者：Gá ; bor Nagy ; Dr. Dezső Szikra ; Dr. Gyö ; rgy Trencsé ; nyi ; Dr. Anikó ; Fekete ; Dr. Ildikó ; Garai ; Dr. Arianna M. Giani ; Dr. Roberto Negri ; Prof. Norberto Masciocchi ; Dr. Alessandro Maiocchi ; Dr. Fulvio Uggeri ; Prof. Imre Tó ; th ; Prof. Silvio Aime ; Prof. Giovanni B. Giovenzana and Dr. Zsolt Baranyai
- 刊名：Angewandte Chemie International Edition
- 出版年：2017
- 出版时间：February 13, 2017
- 年：2017
- 卷：56
- 期：8
- 页码：2118-2122
- 全文大小：1376K
- ISSN：1521-3773
文摘
Unprecedented fast and efficient complexation of Sc<sup>IIIsup> was demonstrated with the chelating agent AAZTA (AAZTA=1,4-bis(carboxymethyl)-6-[bis(carboxymethyl)]amino-6-methylperhydro-1,4-diazepine) under mild experimental conditions. The robustness of the <sup>44sup>Sc(AAZTA)<sup>−sup> chelate and conjugated biomolecules thereof is further shown by in vivo PET imaging in healthy and tumor mice models. The new results pave the way towards development of efficient Sc-based radiopharmaceuticals using the AAZTA chelator.