Preparation of Reactive Oligo(p-Phenylene Vinylene) Materials for Spatial Profiling of the Chemical Reactivity of Intracellular Compartments
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- 作者：Chenyao Nie ; Shengliang Li ; Bing Wang ; Libing Liu ; Rong Hu ; Hui Chen ; Fengting Lv ; Zhihui Dai and Shu Wang
- 刊名：Advanced Materials
- 出版年：2016
- 出版时间：May 18, 2016
- 年：2016
- 卷：28
- 期：19
- 页码：3749-3754
- 全文大小：1803K
- ISSN：1521-4095
文摘
An oligo(p-phenylene vinylene) derivative (OPV-pfp) functionalized with pentafluorophenol active ester is designed and synthesized. The high reactivity of OPV-pfp with biological small molecules or macromolecules containing amino groups under physiological conditions leads to spectral changes of OPV-pfp; thus, spatial reactivity discrimination for different subcellular structures inside cells is realized by triggering and imaging the fluorescence signal change of the OPV-pfp.