Crystal structure of Rv3899c^184-410, a hypothetical protein from Mycobacterium tuberculosis

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• 作者：Yingying Liu ; Yunrong Gao ; Defeng Li ; Joy Fleming ; Honglin Li and Lijun Bi
• 关键词：Mycobacterium tuberculosis ; Rv3899c184&ndash ; 410 ; crystal structure
• 刊名：Acta Crystallographica Section F
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：72
• 期：8
• 页码：642-645
• 全文大小：1183K
• ISSN：1744-3091

文摘

Rv3899c is a hypothetical protein from Mycobacterium tuberculosis which is conserved across mycobacteria. It is predicted to be secreted and has been found in culture filtrates. It has been proposed as a potential vaccine candidate; however, its biological function is unknown. Here, the global structure of Rv3899c^184–410, a fragment of Rv3899c, is reported. The structure resembles the shell of a sea snail, and its N- and C-termini form two relatively independent compact domains: an α/β/α sandwich folding domain and an α-helix bundle domain. There are no reported protein structures for any Rv3899c homologues; this structure provides the first structural glimpse of a new protein family consisting of Rv3899c and its homologues.