Meat and fish consumption and the risk of renal cell carcinoma in the European prospective investigation into cancer and nutrition

详细信息    查看全文

• 作者：Sabine Rohrmann ; Jakob Linseisen ; Kim Overvad ; Anne Mette Lund Wü ; rtz ; Nina Roswall ; Anne Tjonneland ; Marie-Christine Boutron-Ruault ; Antoine Racine ; Nadia Bastide ; Domenico Palli ; Claudia Agnoli ; Salvatore Panico ; Rosario Tumino ; Carlotta Sacerdote ; Steffen Weikert ; Annika Steffen ; Tilman Kü ; hn ; Kuanrong Li ; Kay-Tee Khaw ; Nicholas J. Wareham ; Kathryn E. Bradbury ; Eleni Peppa ; Antonia Trichopoulou ; Dimitrios Trichopoulos ; H.B(as) Bueno-de-Mesquita ; Petra H.M. Peeters ; Anette Hjartå ; ker ; Guri Skeie ; Elisabete Weiderpass ; Paula Jakszyn ; Miren Dorronsoro ; Aurelio Barricarte ; Carmen Santiuste de Pablos ; Esther Molina-Montes ; Ramó ; n Alonso de la Torre ; Ulrika Ericson ; Emily Sonestedt ; Mattias Johansson ; Bö ; rje Ljungberg ; Heinz Freisling ; Isabelle Romieu ; Amanda J. Cross ; Anne-Claire Vergnaud ; Elio Riboli and Heiner Boeing
• 关键词：renal cell cancer ; cohort study ; red meat ; processed meat
• 刊名：International Journal of Cancer
• 出版年：2015
• 出版时间：1 March 2015
• 年：2015
• 卷：136
• 期：5
• 页码：E423-E431
• 全文大小：178K
• ISSN：1097-0215

文摘

Renal cell cancer (RCC) incidence varies worldwide with a higher incidence in developed countries and lifestyle is likely to contribute to the development of this disease. We examined whether meat and fish consumption were related to the risk of RCC in the European Prospective Investigation into Cancer and Nutrition (EPIC). The analysis included 493,179 EPIC participants, recruited between 1992 and 2000. Until December 2008, 691 RCC cases have been identified. Meat and fish consumption was assessed at baseline using country-specific dietary assessment instruments; 24-hour recalls were applied in an 8% subsample for calibration purposes. Cox proportional hazards regression was used to calculate multivariable-adjusted hazard ratios (HR) and 95% confidence intervals (CI). Women with a high consumption of red meat (HR = 1.36, 95% CI 1.14–1.62; calibrated, per 50 g/day) and processed meat (HR = 1.78, 95% CI 1.05–3.03; calibrated, per 50 g/day) had a higher risk of RCC, while no association existed in men. For processed meat, the association with RCC incidence was prominent in premenopausal women and was lacking in postmenopausal women (p interaction = 0.02). Neither poultry nor fish consumption were statistically significantly associated with the risk of RCC. The results show a distinct association of red and processed meat consumption with incident RCC in women but not in men. A biological explanation for these findings remains unclear.