A Novel Synthesis of 2-Ferrocenoyl-Substituted Iodobenzofurans
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- 作者：Yang Li ; Bairenqing Zhuoma and Wentao Gao
- 刊名：Journal of Heterocyclic Chemistry
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：54
- 期：1
- 页码：764-768
- 全文大小：1381K
- ISSN：1943-5193
文摘
In the present investigation, the first construction of a series of structurally new 2-ferrocenoyl-substituted iodobenzofurans hybrids has been achieved through a simple and mild two-step procedure, involving the erm4">iodination of salicylaldehydes using er" xmlns:mml="http://www.w3.org/1998/Math/MathML" id="jhet2625-eo-2000">erm1 TH_term3">N-iodosuccinimide reagent in eco-friendly PEG-400 medium at room temperature followed by one-pot Rap–Stoermer reaction with 1-chloroacetylferrocene in refluxing MeCN with the presence of K2CO3 as base and PEG-400 as the activated additive. These newly synthesized compounds belong to a new class of ferrocene-benzofuran hybrids and could be good candidates for the development of compounds for use in medicinal chemistry.