Production of microparticles of PHBV polymer impregnated with progesterone by supercritical fluid technology

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• 作者：Willyan Machado Giufrida ; Fernando A. Voll ; Andresa Carla Feihrmann ; Marcos H. Kunita ; Ed H. Madureira ; Marcos R. Guilherme ; Dió ; genes R. L. Vedoy ; Vladimir F. Cabral and Lú ; cio Cardozo-Filho
• 刊名：The Canadian Journal of Chemical Engineering
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：94
• 期：7
• 页码：1336-1341
• 全文大小：938K
• ISSN：1939-019X

文摘

This work reports the synthesis of particles based on poly(3-hydroxybutirate-co-3-hydroxyvalerate) (PHBV) polymer that were impregnated with progesterone. The PHBV particles were obtained by supercritical CO₂ (scCO₂) anti-solvent expansion (SAS). scCO₂ was also used at a high pressure (25 MPa) and moderate temperature (323 K) for the impregnation of progesterone into the PHBV particles at different impregnation times. In vitro release tests showed that the half-time of progesterone release in a hydro-alcoholic medium, for the samples produced with impregnation times of 2–32 h, was 3–5 h, with the higher release times generally related to smaller impregnation times.