Palladium-Catalyzed Intramolecular C-H Amination in Water

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• 作者：Lizheng Yang ; Hao Li ; Haifei Zhang and Hongjian Lu
• 刊名：European Journal of Organic Chemistry
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：2016
• 期：34
• 页码：5611-5615
• 全文大小：1127K
• ISSN：1099-0690

文摘

Palladium(II) catalysis was found to be effective for intramolecular C–H amination in water. With 2-azidobiphenyls as substrates, the reaction efficiently provided various carbazoles with N₂ as the sole byproduct. The reaction showed high functional-group tolerance and could be used in the synthesis of several natural carbazole alkaloids. The catalytic process was promoted by water, and the reaction was inefficient in the organic solvents that were investigated.