This artwork presents the basic reaction concept of t
he asymmetric catalytic aza-Diels–Alder/ring-closing cascade by t
he operation mode of a zipper. T
he two molecules (red: 2,4-dienal; blue: hydrazone) in this reaction are mosaicked into t
he two chains of t
he zipper. T
he chiral slider, t
he diarylprolinol-silyl et
her catalyst, zips toget
her t
he two molecules by sliding t
he hand down t
he chains forming t
he bicyclic aza-
heterocyclic products in a highly stereoselective manner. More information can be found in t
he Communication by K. A.
Jørgensen et al. on
hem.201604310" rel="references:https://doi.org/10.1002/chem.201604310">page 38 ff.