3-(3,5-Dimethyl-1H-Pyrazol-1-yl)-3-Oxopropanenitrile as Precursor for Some New Mono-Heterocyclic and Bis-Heterocyclic Compounds

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• 作者：Nadia H. Metwally ; Fathy M. Abdelrazek ; Salwa M. Eldaly and Peter Metz
• 刊名：Journal of Heterocyclic Chemistry
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：54
• 期：1
• 页码：289-294
• 全文大小：781K
• ISSN：1943-5193

文摘

3-(3,5-Dimethyl-1 H -pyrazol-1-yl)-3-oxopropanenitrile het2578-eo-0001" rel="references:#jhet2578-eo-0001"> was used as a cyanoacetylating agent for synthesis of the acetanilide derivative het2578-eo-0003" rel="references:#jhet2578-eo-0003">. Compound het2578-eo-0003" rel="references:#jhet2578-eo-0003"> was utilized as a key intermediate for the synthesis of some new mono-chromene and di-chromene derivatives het2578-eo-0023" rel="references:#jhet2578-eo-0023"> and het2578-eo-0034" rel="references:#jhet2578-eo-0034">, the dihydrazo derivatives het2578-eo-0043" rel="references:#jhet2578-eo-0043">, and the dithiazole derivatives het2578-eo-0052" rel="references:#jhet2578-eo-0052"> via the condensation with o-hydroxybenzaldehyde derivatives, the coupling with aryl diazonium salts, or the reaction with Math/MathML" id="jhet2578-eo-2005">phenyl isothiocyanate in presence of KOH followed by phenacyl bromide derivatives respectively.