The genetic basis of the comorbidity between cannabis use and major depression

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• 作者：Karen Hodgson ; Laura Almasy ; Emma E. M. Knowles ; Jack W. Kent Jr ; Joanne E. Curran ; Thomas D. Dyer ; Harald H. H. Gö ; ring ; Rene L. Olvera ; Mary D. Woolsey ; Ravi Duggirala ; Peter T. Fox ; John Blangero and David C. Glahn
• 刊名：Addiction
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：112
• 期：1
• 页码：113-123
• 全文大小：498K
• ISSN：1360-0443

文摘

While the prevalence of major depression is elevated among cannabis users, the role of genetics in this pattern of comorbidity is not clear. This study aimed to estimate the heritability of cannabis use and major depression, quantify the genetic overlap between these two traits and localize regions of the genome that segregate in families with cannabis use and major depression.