Design and Enantioselective Construction of Axially Chiral Naphthyl-Indole Skeletons
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- 作者：Hong-Hao Zhang ; Cong-Shuai Wang ; Can Li ; Dr. Guang-Jian Mei ; Prof. Dr. Yuxue Li and Prof. Dr. Feng Shi
- 刊名：Angewandte Chemie International Edition
- 出版年：2017
- 出版时间：January 2, 2017
- 年：2017
- 卷：56
- 期：1
- 页码：116-121
- 全文大小：5454K
- ISSN：1521-3773
文摘
The first enantioselective construction of a new class of axially chiral naphthyl-indole skeletons has been established by organocatalytic asymmetric coupling reactions of 2-naphthols with 2-indolylmethanols (up to 99 % yield, 97:3 e.r.). This approach not only affords a new type of axially chiral heterobiaryl backbone, but also provides a new catalytic enantioselective strategy for constructing axially chiral biaryl scaffolds by making use of the C3-electrophilicity of 2-indolylmethanols.