文摘
A simple and efficient synthetic approach is reported for the synthesis of highly functionalized 4-amino-iminocoumarins 4 and 4-aminoquinolines 6 in moderate to excellent yields, through a copper-catalyzed multicomponent reaction. The reaction is carried out in a one-pot manner, using readily available terminal alkynes 1, sulfonyl azides 2, and 2-hydroxybenzonitriles 3 or 2-aminobenzonitrile (5) as substrates at a slightly elevated temperature under N2. The protocol is operationally simple and has a good substrate scope. The overall process involves a nucleophilic addition to a ketenimine, and isomerization of the intermediate.