A Transition-Metal-Free Synthesis of Multisubstituted Imidazoles

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• 作者：Ping Wu ; Lutao Zhang ; Xueguo Zhang ; Xin Guo and Baohua Chen
• 关键词：multisubstituted imidazoles ; cyclization ; benzamidine ; N-tosyl-hydrazone ; heterocycles
• 刊名：Chinese Journal of Chemistry
• 出版年：2016
• 出版时间：April, 2016
• 年：2016
• 卷：34
• 期：4
• 页码：363-367
• 全文大小：345K
• ISSN：1614-7065

文摘

A novel and simple t-BuOLi/I₂-mediated synthesis of 1,2,4-trisubstituted imidazoles was developed without transition-metal added. The transition-metal-free strategy tolerated a range of substrates and provided products in moderate to good yields with 100% regioselectivity.