A novel protein tyrosine phosphatase 1B inhibitor with therapeutic potential for insulin resistance
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- 作者：Xiaolin Zhang ; Jinying Tian ; Juan Li ; Liwei Huang ; Song Wu ; Wei Liang ; Liangwei Zhong ; Jianping Ye and Fei Ye
- 刊名：British Journal of Pharmacology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：173
- 期：12
- 页码：1939-1949
- 全文大小：2062K
- ISSN：1476-5381
文摘
Insulin-sensitizing drugs are currently limited, and identifying new candidates is a challenge. Protein tyrosine phosphatase 1B (PTP1B) negatively regulates insulin signalling, and its inhibition is anticipated to improve insulin resistance. Here, the pharmacological properties of CX08005, a novel PTP1B inhibitor, were investigated.