Copper(I)-Catalyzed Stereoselective Synthesis of (E)--Alkynyl-,β-unsaturated Esters from a Terminal Alkyne, Diazoesters and Aldehydes

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• 作者：Chenggui Wu ; Zhenxing Liu ; Zhikun Zhang ; Fei Ye ; Guisheng Deng ; Yan Zhang and Jianbo Wang
• 刊名：Advanced Synthesis & Catalysis
• 出版年：2016
• 出版时间：July 28, 2016
• 年：2016
• 卷：358
• 期：15
• 页码：2480-2488
• 全文大小：549K
• ISSN：1615-4169

文摘

A new synthetic method for α-alkynyl-α,β-unsaturated esters is presented herein. The method is based on a copper(I)-catalyzed three-component reaction of a terminal alkyne, diazoesters and aldehydes. The reaction is featured by mild conditions, high yields and excellent stereoselectivity. Cu(I) carbene migratory insertion is proposed as the key step in the transformation.