Antibacterial and antifouling properties of a polyurethane surface modified with perfluoroalkyl and silver nanoparticles

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• 作者：Deqiu Xu ; Yuling Su ; Lili Zhao ; Fancui Meng ; Chang Liu ; Yayuan Guan ; Jiya Zhang and Jianbin Luo
• 刊名：Journal of Biomedical Materials Research Part A
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：105
• 期：2
• 页码：531-538
• 全文大小：860K
• ISSN：1552-4965

文摘

Inspired by mussel-adhesion phenomena in nature, a simple, mild surface modification process was elaborated to endow the polyurethane (PU) substrate with antibacterial/antifouling properties. In the present study, polydopamine was coated directly onto polyurethane surfaces. AgNO₃ was then added and absorbed onto the surface by the active catechol and amine groups of the polydopamine coating. Meanwhile, the adsorbed Ag⁺ ions were reduced in situ into metallic silver nanoparticles by the “bridge” of the polydopamine coating which yielded a coating with good antimicrobial properties. Finally, 1H, 1H, 2H, 2H-perfluorodecanethiol (CF₃(CF₂)₇CH₂CH₂SH, F-SH) was attached on the PDA coating via the Michael addition reaction. The hydrophobic F-SH layer above the antibacterial layer yielded a surface with excellent antifouling properties. Preliminary antibacterial assays indicate that the coated surfaces show enhanced antibacterial activity against Escherichia coli (Gram-negative bacteria) and Staphylococcus aureus (Gram-positive bacteria). Platelet adhesion was significantly reduced for the F-SH-coated PU film. These results suggest that the modified PU could be used as an antibacterial material for future biomedical applications.