Designed Stem Cell Aggregates: Enhanced Biological Functions of Human Mesenchymal Stem-Cell Aggregates Incorporating E-Cadherin-Modified PLGA Microparticles (Adv. Healthcare Mater. 15/2016)
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- 作者：Yan Zhang ; Hongli Mao ; Chao Gao ; Suhua Li ; Qizhi Shuai ; Jianbin Xu ; Ke Xu ; Lei Cao ; Ren Lang ; Zhongwei Gu ; Toshihiro Akaike and Jun Yang
- 刊名：Advanced Healthcare Materials
- 出版年：2016
- 出版时间：August 10, 2016
- 年：2016
- 卷：5
- 期：15
- 页码：1992
- 全文大小：2096K
- ISSN：2192-2659
文摘
E-cadherin-modified poly(lactic-co-glycolic acid) (hE-cad-PLGA) microparticles were fabricated and then mediated the 3D cell aggregates of human mesenchymal stem cells (MSCs) on page 1949 by Jun Yang and co-workers. The hE-cad-Fc matrix and the PLGA microparticles synergistically regulate the proliferation and bioactive factors secretions of MSCs by activating EGFR, AKT and ERK1/2 signaling pathways. The hE-cad-PLGA microparticles offer a novel route to expand multipotent stem cell-based clinical applications.