The Construction of X-CN (X=N, S, O) Bonds

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• 作者：Jin-Tao Yu ; Fan Teng and Jiang Cheng
• 刊名：Advanced Synthesis & Catalysis
• 出版年：2017
• 出版时间：January 4, 2017
• 年：2017
• 卷：359
• 期：1
• 页码：26-38
• 全文大小：2637K
• ISSN：1615-4169

文摘

The cyano moiety is a common and important functional group that exists in a myriad of medicinal molecules and natural products. Moreover, nitriles serve as versatile precursors that can readily be converted into diverse functional groups as well as the nitrogen-containing cyclic molecules. As a result, cyanation has become a significant type of transformation in organic chemistry. However, in comparison with the well-developed C-cyanation, few works have been reported dealing with the N-, S- and O-cyanation processes. Apart from the classical von Braun reaction, chemists have developed a number of methods with various cyanating reagents to achieve such X-cyanations (X=N, S, O). In this review, recent advances (especially those after 2000) in the X–CN (X=N, S, O) bond formation are summarized with discussion and the outlooks are also listed.