Nanoarchitectonics is defined as the arrangement of molecules at the nanometer scale for functional-material fabrication. In this artwork, a bienzyme architecture immobilized onto two-dimensional graphene oxide scaffold is shown. Direct molecular channeling of substrates between enzymes is demonstrated. It was found that the hydrophobicity of graphene oxides and various enzyme architectures for co-immobilized systems are important attributes for achieving high product-conversion rates. This work provides insights that help to avoid the current unnecessary complications involved in spatial organization of bienzyme systems. More information can be found in the Full Paper by W. Yang et al. on page 304 ff.