Interleukin (IL) 31 induces in cynomolgus monkeys a rapid and intense itch response that can be inhibited by an IL-31 neutralizing antibody
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- 作者：K.E. Lewis ; M.S. Holdren ; M.F. Maurer ; S. Underwood ; B. Meengs ; S.H. Julien ; K.A. Byrnes-Blake ; J.A. Freeman ; T.R. Bukowski ; A.C. Wolf ; N.B. Hamacher ; M.W. Rixon and S.R. Dillon
- 刊名：Journal of the European Academy of Dermatology and Venereology
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：31
- 期：1
- 页码：142-150
- 全文大小：224K
- ISSN：1468-3083
文摘
Overexpression or administration of interleukin 31 (IL-31) has been shown to induce a profound itch response in mice and dogs. The chronic pruritus observed in mouse IL-31 transgenic mice results in the development of skin lesions and alopecia through excoriation from excessive scratching, a condition similar to that observed in patients with atopic dermatitis (AD).