Gold-Quantum Dot Core-Satellite Assemblies for Lighting Up MicroRNA In Vitro and In Vivo

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• 作者：Xueli Zhao ; Liguang Xu ; Maozhong Sun ; Wei Ma ; Xiaoling Wu ; Hua Kuang ; Libing Wang and Chuanlai Xu
• 刊名：Small
• 出版年：2016
• 出版时间：September 14, 2016
• 年：2016
• 卷：12
• 期：34
• 页码：4662-4668
• 全文大小：5206K
• ISSN：1613-6829

文摘

A high yield DNA-driven gold-quantum dot core–satellite is developed for miRNA detection in vitro and vivo. In the presence of the target miRNA, the DNA hairpin between core and satellite is ruined, resulting in the recovery of fluorescence. The limit of detection for miRNA-21 detection in living cells reaches 296 copies per cell.