RNA Detection: Gold-Quantum Dot Core-Satellite Assemblies for Lighting Up MicroRNA In Vitro and In Vivo (Small 34/2016)

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• 作者：Xueli Zhao ; Liguang Xu ; Maozhong Sun ; Wei Ma ; Xiaoling Wu ; Hua Kuang ; Libing Wang and Chuanlai Xu
• 刊名：Small
• 出版年：2016
• 出版时间：September 14, 2016
• 年：2016
• 卷：12
• 期：34
• 页码：4581
• 全文大小：2276K
• ISSN：1613-6829

文摘

On page 4662, a core-satellite structure was fabricated by H. Kuang and co-workers using partly-complementary-DNA-functionalized Au NPs of 35 ± 2 nm and quantum dots (QDs) of 6 ± 1 nm. The fluorescence of the QD satellites was quenched after assembly with the Au core. In the presence of the target miR, the hairpin sequence of the core-satellite assembly was destroyed by DNA hybridization, leading to the restoration of fluorescence.