Gartanin, an isoprenylated xanthone from the mangosteen fruit (Garcinia mangostana), is an androgen receptor degradation enhancer

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• 作者：Gongbo Li ; Sakina M. Petiwala ; Miao Yan ; Jong Hoon Won ; Pavel A. Petukhov and Jeremy J. Johnson
• 刊名：Molecular Nutrition & Food Research
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：60
• 期：6
• 页码：1458-1469
• 全文大小：3366K
• ISSN：1613-4133

文摘

Androgen receptor (AR) has been a target of prostate cancer for nearly seven decades. In the last several years there has been an interest in identifying compounds that promote degradation of the androgen receptor. In the present study, gartanin, an isoprentylated xanthone in the mangosteen fruit, was evaluated for enhancing AR degradation, and inducing the unfolded protein response pathway.