2-Bromo-1-(1H-pyrazol-4-yl)ethanone: Versatile Precursor for Novel Mono- and Bis[pyrazolylthiazoles]

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• 作者：Mostafa E. Salem ; Ahmed F. Darweesh ; Ahmed E. M. Mekky ; Ahmad M. Farag and Ahmed H. M. Elwahy
• 刊名：Journal of Heterocyclic Chemistry
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：54
• 期：1
• 页码：226-234
• 全文大小：783K
• ISSN：1943-5193

文摘

The synthesis of novel bis(thiazoles) and is reported. Thus, reaction of 2-bromo-1-(5-methyl-1-phenyl-1H-pyrazol-4-yl)ethanone () with the corresponding thioamide derivatives ,, in refluxing EtOH in the presence of triethylamine, afforded 4-pyrazolylthiazoles in good yields. On the other hand, the novel bis(thiazoles) and were obtained from the reaction of with the corresponding benzaldehyde thiosemicarbazones , in refluxing EtOH. Compounds and were obtained by condensation of the corresponding bis(aldehydes) and with thiosemicarbazide.