Alamandine abrogates neutrophil degranulation in atherosclerotic mice
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- 作者：Analina R. Da Silva ; Sé ; bastien Lenglet ; Federico Carbone ; Fabienne Burger ; Aline Roth ; Luca Liberale ; Aldo Bonaventura ; Franco Dallegri ; Nikolaos Stergiopulos ; Robson A. S. Santos ; Franç ; ois Mach ; Rodrigo A. Fraga-Silva and Fabrizio Montecucco
- 刊名：European Journal of Clinical Investigation
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：47
- 期：2
- 页码：117-128
- 全文大小：661K
- ISSN：1365-2362
文摘
Neutrophil-mediated inflammation was recently identified as an active contributor to athero-progression. Therapeutic strategies inhibiting neutrophil degranulation or recruitment were hypothesized to positively impact on plaque vulnerability. In this study, we investigated whether treatment with the recently discovered agonist of the Mas-related G-coupled receptor type D (MrgD) alamandine would impact on neutrophil degranulation in vivo and in vitro.