Functional analysis of human cytomegalovirus UL/b′ region using SCID-hu mouse model
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- 作者：Kalpana Dulal ; Tong Cheng ; Lianwei Yang ; Wei Wang ; Ying Huang ; Benjamin Silver ; Anca Selariu ; Cynthia Xie ; Dai Wang ; Amy Espeseth ; Yanzhen Lin ; Lanling Wen ; Ningshao Xia ; Tong-Ming Fu and Hua Zhu
- 刊名：Journal of Medical Virology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：88
- 期：8
- 页码：1417-1426
- 全文大小：1773K
- ISSN：1096-9071
文摘
Human cytomegalovirus (HCMV) attenuated strains, Towne, and AD169, differ from prototypic pathogenic strains, such as Toledo, in that they are missing a ∼15-kb segment in the UL/b′ region. In contrast to the attenuated strains, Toledo can replicate in human tissue implants in SCID (SCID-hu) mice. Thus, this model provides a unique in vivo system to study the mechanism of viral pathogenesis. Twenty-two ORFs have been annotated in the UL/b′ region, including tissue-tropic genes encoded in a pentameric gH/gl complex.